Myoglobin (MYO) Antibody & Antigen
Myoglobin (MYO) antibody and antigen raw materials for immunoassay development, reagent screening and rapid-test optimization. Source: Mouse (Antibody) / E. coli (Antigen); application: Myocardial / Skeletal Muscle Injury.
Background
Myoglobin (Myoglobin, Mb) is a mammalian cell (mainly muscle cells) oxygen storage and distribution of protein, it is made up of a polypeptide chain and a prosthetic group heme, relative molecular mass is 16, 700, including 153 amino acid residues.
In addition to heme, apomyoglobin is called globin, which has obvious homology with the subunit of hemoglobin (a-globin chain and p-globin chain) in the amino acid sequence, and their conformation and function are extremely similar.
Clinical Significance
Measurement of serum myoglobin may be the most sensitive index in the early diagnosis of acute myocardial infarction (AMI).
But with its poor specificity, skeletal muscle injury, trauma, renal failure and other diseases can all lead to its elevation.
Although MYO positive cannot diagnose AMI, it can be used to exclude the important indicators of AMI diagnosis in the early stage. For example, MYO negative can basically exclude myocardial infarction, and can also be used for the diagnosis of re-infarction. In combination with clinical practice, if MYO is elevated again, reinfarction or infarct extension should be considered.
Increase: early acute myocardial infarction, acute muscle injury, muscular dystrophy, muscular atrophy, multiple myositis, acute or chronic renal failure, severe congestive heart failure and long-term shock.
It can be increased at 1.5h after myocardial infarction, but returns to normal within 1-2d.
(1) elevated blood level: hypothyroidism, hyperaldosteronism, renal insufficiency, malignant high fever, and after strenuous exercise.
(2) elevated urine: porphyria, hemoglobinuria, hematuria, etc.
(3) increased myoglobin in blood and urine: seen in acute myocardial infarction, angina, cardiogenic shock, cardiomyopathy, myopathy (progressive muscular dystrophy, multiple myositis, myasthenia gravis), etc.
Product Parameters
The detection alone is meaningless, and it is generally combined with cTnI and CKMB, with insignificant sensitivity and low clinical requirements. The cutoff value is 50-80ng/ml.
| Material / Clone | Type | Code | Source | Application | Recommended Use |
|---|---|---|---|---|---|
| MYO Antigen | rAg | FAMY28 | E. coli (Antigen) | EIA, LF | Quality Control |
| MYO-12E3 | mAb | FBMY47 | Mouse (Antibody) | EIA, LF | Coating |
| MYO-5G4 | mAb | FBMY2 | Mouse (Antibody) | EIA, LF | Labeling |
| MYO-8E3 | mAb | FBMY3 | Mouse (Antibody) | EIA, LF | Labeling |
| MYO Antibody | mAb | ABMY6 | Mouse (Antibody) | EIA, LF | - |
| MYO Antigen | Ag | AAMY7 | E. coli (Antigen) | EIA, LF | - |
| MYO Antibody | mAb | OBMY2 | Mouse (Antibody) | EIA, LF | - |
| MYO Antibody | mAb | OBMY9 | Mouse (Antibody) | EIA, LF | - |
| MYO Antigen | rAg | OAMY6 | E. coli (Antigen) | EIA, LF | - |
| MYO Raw Material Set | Raw Material Set | RMMY3 | Mouse (Antibody) | EIA, LF | - |